Ammonium Hydroxide → HCID 15053448, 화합물

HRID 974614노트

반응식

HRID 974614 반응식
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([O:6][CH:7]2[CH2:10][N:9]([C:11](Cl)=[O:12])[CH2:8]2)=[CH:4][CH:3]=1.[OH-].[NH4+:17]>O1CCCC1.O>[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([O:6][CH:7]2[CH2:10][N:9]([C:11]([NH2:17])=[O:12])[CH2:8]2)=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 14923Ammonium HydroxideHCID 15042229HCID 15042229, 화합물

생성물 1

HCID 15053448HCID 15053448, 화합물수율 52.9%

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 5 g (0.02 mole) of 3-(4-chlorophenoxy)-1-azetidinecarbonyl chloride in 20 ml of tetrahydrofuran was stirred while 4 ml (0.06 mole) of 57% ammonium hydroxide was added all at once. After stirring for 18 hr, the reaction mixture was diluted with 200 ml of water and the solid which separated was collected by filtration, 10.5 g. Recrystallization from isopropanol yielded 2.4 g (52.9%) of gray crystalline powder, m.p. 187°-188° C.

후처리

  1. additionwas added all at once
  2. customthe solid which separated
  3. filtrationwas collected by filtration, 10.5 g
  4. customRecrystallization from isopropanol

출처 및 근거

ORD 기록
ord-c6eb296d65eb4e44aed771720a40f514
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05068231

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