Ammonia → trans-3-Amino-1-benzyl-4-hydroxy-pyrrolidine
반응식
[CH2:1]([N:8]1[CH2:13][CH:12]2[CH:10]([O:11]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH3:14]>>[NH2:14][C@H:10]1[C@H:12]([OH:11])[CH2:13][N:8]([CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH2:9]1참가 물질
3
실험 절차
8.9 g (50 mmol) of 3-benzyl-6-oxa-3-azabicyclo[3.1.0]hexane are heated in 75 ml of ammonia solution (25% strength) at 120° C. in an autoclave for 8 hours. The solution is concentrated and the residue is distilled.
후처리
- concentrationThe solution is concentrated
- distillationthe residue is distilled
출처 및 근거
- ORD 기록
- ord-1d73cae6917b4ac7977504590f550937
- 출처 데이터셋
- uspto-grants-1997_03
- 특허 번호
- US05607942
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