N-Carbethoxyphthalimide → N-(1-benzylpyrrolidin-3-yl)phthalimide

HRID 975005노트

반응식

HRID 975005 반응식
[NH2:1][CH:2]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:3]1.C(OC(N1[C:23](=[O:24])[C:22]2=[CH:25][CH:26]=[CH:27][CH:28]=[C:21]2[C:20]1=[O:29])=O)C>ClC>[CH2:7]([N:4]1[CH2:5][CH2:6][CH:2]([N:1]2[C:23](=[O:24])[C:22]3=[CH:25][CH:26]=[CH:27][CH:28]=[C:21]3[C:20]2=[O:29])[CH2:3]1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 31187N-CarbethoxyphthalimideHCID 27566131-Benzyl-3-aminopyrrolidine

생성물 1

HCID 6711061N-(1-benzylpyrrolidin-3-yl)phthalimide수율 73.3%

시약·촉매·용매 1

HCID 6327Methyl Chloride용매

실험 절차

10.0 g of 3-amino-1-benzylpyrrolidine was dissolved into 10 ml of chloromethane, to which 12.4 g of N-ethoxycarbonylphthalimide was added and stirred at a room temperature for 10 hours. The solvent was distilled off, diethyl ether was added and insoluble matters were filtered out. The filtrate was concentrated and purified on silica gel column chromatography, to obtain 12.70 g of the above-captioned compound (yield: 73%)

후처리

  1. additionwas added
  2. distillationThe solvent was distilled off
  3. additiondiethyl ether was added
  4. filtrationinsoluble matters were filtered out
  5. concentrationThe filtrate was concentrated
  6. custompurified on silica gel column chromatography

출처 및 근거

ORD 기록
ord-132544e9f0484098ab1594f7a0dadfe7
출처 데이터셋
uspto-grants-1997_03
특허 번호
US05607953

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