Sodium Bicarbonate → 4-Methyl-5-propionyloxazole

HRID 975038

반응식

HRID 975038 반응식
CON(C)[C:4]([C:6]1[O:10][CH:9]=[N:8][C:7]=1[CH3:11])=[O:5].[CH2:13]([Mg]Br)[CH3:14].C(=O)([O-])O.[Na+]>O1CCCC1>[CH3:11][C:7]1[N:8]=[CH:9][O:10][C:6]=1[C:4](=[O:5])[CH2:13][CH3:14]

참가 물질

5

반응물 3

HCID 516892Sodium BicarbonateHCID 18925369N-Methoxy-N,4-dimethyloxazole-5-carboxamideHCID 178418443HCID 178418443, 화합물

생성물 1

HCID 189363294-Methyl-5-propionyloxazole

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

N-Methoxy-N-methyl-4-methyl-5-oxazolecarboxamide (5 g) in dry tetrahydrofuran at -40° C. was stirred under a nitrogen atmosphere and ethylmagnesium bromide (1M solution in tetrahydrofuran, 35 ml) was added dropwise. After 30 minutes the mixture was allowed to warm to room temperature and then stirred for a further 1 hour. Aqueous sodium hydrogen carbonate was added, the organic layer was separated and the aqueous layer was extracted with diethylether. The material thus obtained was purified by flash chromatography to yield a pale yellow liquid which solidified on cooling.

후처리

  1. customthe organic layer was separated
  2. extractionthe aqueous layer was extracted with diethylether
  3. customThe material thus obtained
  4. customwas purified by flash chromatography
  5. customto yield a pale yellow liquid which
  6. temperatureon cooling

출처 및 근거

ORD 기록
ord-14f1b749a0f249299ac8e0e73b1a91bb
출처 데이터셋
uspto-grants-1997_03
특허 번호
US05607956

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