Ethanol → 1-(3-Furyl)-1-(4-methyl-5-oxazolyl)ethanol

HRID 975047

반응식

HRID 975047 반응식
[CH3:1][C:2]1[N:3]=[CH:4][O:5][C:6]=1[C:7]([C:9]1[CH:13]=[CH:12][O:11][CH:10]=1)=[O:8].C[Li].[CH2:16](O)C.[Cl-].[Na+]>C(OCC)C>[O:11]1[CH:12]=[CH:13][C:9]([C:7]([C:6]2[O:5][CH:4]=[N:3][C:2]=2[CH3:1])([OH:8])[CH3:16])=[CH:10]1

참가 물질

6

반응물 4

HCID 702EthanolHCID 5234Sodium ChlorideHCID 189363073-Furyl 4-Methyl-5-oxazolyl KetoneHCID 178418348HCID 178418348, 화합물

생성물 1

HCID 97941531-(3-Furyl)-1-(4-methyl-5-oxazolyl)ethanol

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

3-Furyl 4-methyl-5-oxazolyl ketone (1 g) in dry diethylether (15 ml) at -70° C. under a nitrogen atmosphere was treated dropwise with methyllithium (1.5M solution in diethylether, 4.1 ml). After 45 minutes the reaction mixture was allowed to warm to room temperature and ethanol (2 ml) was added. The mixture was poured into saturated aqueous sodium chloride and extracted with dichloromethane. Chromatography and crystallisation then gave 1-(3-furyl)-1-(4-methyl-5-oxazolyl)ethanol identical to the material obtained in (a) above.

후처리

  1. extractionextracted with dichloromethane
  2. customChromatography and crystallisation

출처 및 근거

ORD 기록
ord-74524d204b7e49309002d4e65c9bb569
출처 데이터셋
uspto-grants-1997_03
특허 번호
US05607956

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