Acetone → 5-(2,2-dimethyl-1,3-dioxolan-4-yl)-3,4-dihydroxy-2(5H)-furanone

HRID 975128노트

반응식

HRID 975128 반응식
[O:1]=[C:2]1[O:8][C@H:7]([C@H:9]([CH2:11][OH:12])[OH:10])[C:5]([OH:6])=[C:3]1[OH:4].C(Cl)(=O)C.[CH3:17][C:18]([CH3:20])=O>>[CH3:17][C:18]1([CH3:20])[O:10][CH:9]([CH:7]2[O:8][C:2](=[O:1])[C:3]([OH:4])=[C:5]2[OH:6])[CH2:11][O:12]1

참가 물질

4

반응물 3

HCID 180AcetoneHCID 6367Acetyl chlorideHCID 54670067L-Ascorbic Acid2회

생성물 1

HCID 546765085-(2,2-dimethyl-1,3-dioxolan-4-yl)-3,4-dihydroxy-2(5H)-furanone수율 79%

실험 절차

Initially, 5,6-O-isopropylidene-L-ascorbic acid (IAA) was prepared by adding L-ascorbic acid (100 gm, 0.57 mole) into a three-necked 1-liter flask equipped with a mechanical stirrer and a thermometer. The L-ascorbic acid was followed by acetone (450 ml) and acetyl chloride (12.5 ml), and the whole mixture was stirred vigorously at 30°-40° C. for 2 hours.

후처리

  1. customequipped with a mechanical stirrer

출처 및 근거

ORD 기록
ord-365ad763ecb7481890b98dfd3a4e50b0
출처 데이터셋
uspto-grants-1997_03
특허 번호
US05607968

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