Thionyl Chloride → 4,4-Dimethyl-2-(4'-chloromethylbiphenyl-2-yl)oxazoline

HRID 975291노트

반응식

HRID 975291 반응식
[CH3:1][C:2]1([CH3:21])[CH2:6][O:5][C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[C:13]2[CH:18]=[CH:17][C:16]([CH2:19]O)=[CH:15][CH:14]=2)=[N:3]1.S(Cl)([Cl:24])=O.C(=O)([O-])O.[Na+]>C(Cl)Cl>[CH3:1][C:2]1([CH3:21])[CH2:6][O:5][C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[C:13]2[CH:18]=[CH:17][C:16]([CH2:19][Cl:24])=[CH:15][CH:14]=2)=[N:3]1

참가 물질

5

반응물 3

HCID 24386Thionyl ChlorideHCID 516892Sodium BicarbonateHCID 110658764,4-Dimethyl-2-(4'hydroxymethylbiphenyl-2-yl)oxazoline

생성물 1

HCID 109794774,4-Dimethyl-2-(4'-chloromethylbiphenyl-2-yl)oxazoline

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

1.0 (3.55 mmol) of 4,4-dimethyl-2-(4'-hydroxymethylbiphenyl-2-yl)oxazoline was dissolved in methylene chloride (15 ml). Under cooling with ice, 0.51 g (4.29 mmol) of thionyl chloride was dropwise added thereto, followed by stirring for one hour. The reaction liquid was poured into an aqueous solution of sodium hydrogencarbonate, followed by the extraction with methylene chloride. After washing with water and drying, vacuum concentration was conducted. 1.05 g of the title compound was obtained as a crystal (yield 99%).

후처리

  1. additionwas dropwise added
  2. customThe reaction liquid
  3. extractionfollowed by the extraction with methylene chloride
  4. washAfter washing with water
  5. customdrying
  6. concentrationvacuum concentration

출처 및 근거

ORD 기록
ord-799eee40f9cf4611bb77e9b7c4cf916c
출처 데이터셋
uspto-grants-1997_03
특허 번호
US05608068

반응 노트

불러오는 중…