참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 6-(Methoxycarbonyl)pyridine-3-carboxylic acid | HCID 579631 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 5-Chlorocarbonyl-pyridine-2-carboxylic acid methyl ester | HCID 15121177 | — |
반응 단계
14.5 g (80 mmol) of 2-methoxycarbonylpyridine-5-carboxylic acid are treated with 6.48 ml of thionyl chloride and 2 ml of anhydrous N,N-dimethylformamide in 200 ml of anhydrous toluene. The mixture is heated at 70° C. for 3 h with stirring. It is then concentrated in vacuo and the residue is dissolved in 150 ml of tetrahydrofuran.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05607954 |
|---|
| 출처 데이터셋 | uspto-grants-1997_03 |
|---|
| ORD ID | ord-b7ff8f5cd07e44dab300a97985b59738 |
|---|
| 출처 메모 | uspto-grants-1997_03 |
|---|
