Dimethylformamide → 5-Chlorocarbonyl-pyridine-2-carboxylic acid methyl ester

HRID 975320

반응식

HRID 975320 반응식
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([OH:13])=O)=[CH:7][N:6]=1)=[O:4].S(Cl)([Cl:16])=O.CN(C)C=O>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([Cl:16])=[O:13])=[CH:7][N:6]=1)=[O:4]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 5796316-(Methoxycarbonyl)pyridine-3-carboxylic acid

생성물 1

HCID 151211775-Chlorocarbonyl-pyridine-2-carboxylic acid methyl ester

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
70 °C

실험 절차

14.5 g (80 mmol) of 2-methoxycarbonylpyridine-5-carboxylic acid are treated with 6.48 ml of thionyl chloride and 2 ml of anhydrous N,N-dimethylformamide in 200 ml of anhydrous toluene. The mixture is heated at 70° C. for 3 h with stirring. It is then concentrated in vacuo and the residue is dissolved in 150 ml of tetrahydrofuran.

후처리

  1. concentrationIt is then concentrated in vacuo
  2. dissolutionthe residue is dissolved in 150 ml of tetrahydrofuran

출처 및 근거

ORD 기록
ord-b7ff8f5cd07e44dab300a97985b59738
출처 데이터셋
uspto-grants-1997_03
특허 번호
US05607954

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