Sodium Azide → 9-Azidononanoic acid

HRID 975789노트

반응식

HRID 975789 반응식
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11].[N-:13]=[N+:14]=[N-:15].[Na+]>CN(C=O)C>[N:13]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[N+:14]=[N-:15]

참가 물질

4

반응물 2

HCID 33557Sodium AzideHCID 5482219-Bromononanoic Acid

생성물 1

HCID 152305499-Azidononanoic acid수율 84%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

9-Bromo-nonanoic acid (3.82 g, 17 mmol) was dissolved in DMF (30 mL) and sodium azide (1.11 g, 17 mmol) was added. The solution was heated to 80° C. and stirred overnight. The reaction was poured onto ice and extracted with DCM (3×200 mL). The combined extracts were washed with water (3×200 mL), brine (200 mL), and dried over MgSO4. The solvent was removed in vacuo to give a clear oil 2.83 g (84% yield);

후처리

  1. additionThe reaction was poured onto ice
  2. extractionextracted with DCM (3×200 mL)
  3. washThe combined extracts were washed with water (3×200 mL), brine (200 mL)
  4. dry with materialdried over MgSO4
  5. customThe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-333c8f3b075d4549a5e311cc160ff929
출처 데이터셋
uspto-grants-1997_03
특허 번호
US05610145

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