HCID 86750537, 화합물 → HCID 19968005, 화합물

HRID 975977노트

반응식

HRID 975977 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]2[CH2:12][CH2:11][CH:10]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[N:9]2[C:19](=[O:36])[CH2:20][NH:21][C:22](=[O:35])[NH:23][C:24]2[CH:25]=[C:26]([CH2:30][C:31]([O:33]C)=[O:32])[CH:27]=[CH:28][CH:29]=2)[CH:5]=[CH:6][CH:7]=1>CO>[OH:1][C:2]1[CH:3]=[C:4]([CH:8]2[CH2:12][CH2:11][CH:10]([C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:9]2[C:19](=[O:36])[CH2:20][NH:21][C:22](=[O:35])[NH:23][C:24]2[CH:25]=[C:26]([CH2:30][C:31]([OH:33])=[O:32])[CH:27]=[CH:28][CH:29]=2)[CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 1

HCID 86750537HCID 86750537, 화합물

생성물 1

HCID 19968005HCID 19968005, 화합물수율 44.8%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

By proceeding in a fashion similar to that described in Example 9, but starting from 0.46 g of methyl (2RS,5SR)-3-{3-{2-[2-(3-hydroxyphenyl)-5-phenyl-1-pyrrolidinyl]-2-oxoethyl}ureido}phenylacetate in solution in 10 cm3 of methanol and 0.1 g of potassium hydroxide in solution in 2 cm3 of water, and after treatment and recrystallization in ethanol, 0.2 g of (2RS,5SR)-3-{3-{2-[2-(3-hydroxyphenyl)-5-phenyl-1-pyrrolidinyl]-2-oxoethyl}ureido}phenylacetic acid, melting at 166° C., is obtained.

후처리

  1. custom0.1 g of potassium hydroxide in solution in 2 cm3 of water, and after treatment and recrystallization in ethanol

출처 및 근거

ORD 기록
ord-ab8f15e057974c58a212b106cfed0449
출처 데이터셋
uspto-grants-1997_03
특허 번호
US05610144

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