(E)-N-(5,6-dihydro-7H-cyclopenta[d]pyrimidin-4-yl)-4-[4-(1-benzylpiperidin-4-yl)-2-butenoyl]aniline → N-(5,6-dihydro-7H-cyclopenta[d]pyrimidin-4-yl)-4-[4-(1-benzylpiperidin-4-yl)butanoyl]aniline

HRID 976134노트

반응식

HRID 976134 반응식
[N:1]1[C:6]2[CH2:7][CH2:8][CH2:9][C:5]=2[C:4]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([C:17](=[O:34])/[CH:18]=[CH:19]/[CH2:20][CH:21]3[CH2:26][CH2:25][N:24]([CH2:27][C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[CH2:23][CH2:22]3)=[CH:13][CH:12]=2)=[N:3][CH:2]=1>[Pt]=O.C(O)C>[N:1]1[C:6]2[CH2:7][CH2:8][CH2:9][C:5]=2[C:4]([NH:10][C:11]2[CH:12]=[CH:13][C:14]([C:17](=[O:34])[CH2:18][CH2:19][CH2:20][CH:21]3[CH2:26][CH2:25][N:24]([CH2:27][C:28]4[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=4)[CH2:23][CH2:22]3)=[CH:15][CH:16]=2)=[N:3][CH:2]=1

참가 물질

4

반응물 1

HCID 19968897(E)-N-(5,6-dihydro-7H-cyclopenta[d]pyrimidin-4-yl)-4-[4-(1-benzylpiperidin-4-yl)-2-butenoyl]aniline

생성물 1

HCID 19968926N-(5,6-dihydro-7H-cyclopenta[d]pyrimidin-4-yl)-4-[4-(1-benzylpiperidin-4-yl)butanoyl]aniline수율 78.8%

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 702Ethanol용매

실험 절차

30 ml of ethanol and 0.1 g of platinum oxide were added to 0.24 g of (E)-N-(5,6-dihydro-7H-cyclopenta[d]pyrimidin-4-yl)-4-[4-(1-benzylpiperidin-4-yl)-2-butenoyl]aniline, and the mixture was stirred at room temperature under a hydrogen stream for 45 minutes. After removing the solid by filtration, the solvent was removed by distillation and the obtained residue was applied to silica gel column chromatography to obtain 0.19 g of the title compound as white powder.

후처리

  1. customAfter removing the solid
  2. filtrationby filtration
  3. customthe solvent was removed by distillation

출처 및 근거

ORD 기록
ord-b1ae639c5410425bb5306b17bc92be40
출처 데이터셋
uspto-grants-1997_03
특허 번호
US05610303

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