Methyl 3-[3,5-Diisopropyl-4-(1-phenyltetrazol-5-yloxy)benzoyl]propionate → Methyl 3-(3,5-diisopropylbenzoyl)propionate

HRID 976352노트

반응식

HRID 976352 반응식
[CH:1]([C:4]1[CH:5]=[C:6]([CH:15]=[C:16]([CH:30]([CH3:32])[CH3:31])[C:17]=1OC1N(C2C=CC=CC=2)N=NN=1)[C:7]([CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])=[O:8])([CH3:3])[CH3:2]>C1C=CC=CC=1.[Pd]>[CH:1]([C:4]1[CH:5]=[C:6]([CH:15]=[C:16]([CH:30]([CH3:32])[CH3:31])[CH:17]=1)[C:7]([CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])=[O:8])([CH3:3])[CH3:2]

참가 물질

4

반응물 1

HCID 19967146Methyl 3-[3,5-Diisopropyl-4-(1-phenyltetrazol-5-yloxy)benzoyl]propionate

생성물 1

HCID 19967165Methyl 3-(3,5-diisopropylbenzoyl)propionate수율 71.7%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 241Benzene용매

실험 절차

14.1 g of Methyl 3-[3,5-diisopropyl-4-(1-phenyltetrazol-5-yloxy)benzoyl]propionate was dissolved in 100 ml of benzene, followed by the addition of 10 g of 10% palladium/carbon. The obtained mixture was subjected to hydrogenation under a pressure of 3 kg/cm2, at room temperature for 14 hours. The reaction mixture thus obtained was filtered to remove the catalyst. The filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel chromatography (developer: 3% ethyl acetate/n-hexane) to give 6.4 g of the title compound as a colorless oil.

후처리

  1. customThe reaction mixture thus obtained
  2. filtrationwas filtered
  3. customto remove the catalyst
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. customThe obtained residue was purified by silica gel chromatography (developer: 3% ethyl acetate/n-hexane)

출처 및 근거

ORD 기록
ord-3a3b8643fb8147ee844d1f66562560c3
출처 데이터셋
uspto-grants-1997_03
특허 번호
US05612356

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