Ethanol hydrochloride → 1-(Benzo[b]thiophen-5-yl)-2-[(piperazin-2-yl)methoxy]ethanol dihydrochloride

HRID 976549노트

반응식

HRID 976549 반응식
[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]=[C:7]([CH:10]([OH:24])[CH2:11][O:12][CH2:13][CH:14]3[CH2:19][N:18](C=O)[CH2:17][CH2:16][N:15]3C=O)[CH:8]=[CH:9][C:2]1=2.[ClH:25].C(O)C>CO>[ClH:25].[ClH:25].[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]=[C:7]([CH:10]([OH:24])[CH2:11][O:12][CH2:13][CH:14]3[CH2:19][NH:18][CH2:17][CH2:16][NH:15]3)[CH:8]=[CH:9][C:2]1=2

참가 물질

4

반응물 2

HCID 21887872Ethanol hydrochlorideHCID 53826975(Benzo[b]thiophen-5-yl)-2-[(1,4-diformylpiperazin-2-yl)methoxy]ethanol

생성물 1

HCID 675982851-(Benzo[b]thiophen-5-yl)-2-[(piperazin-2-yl)methoxy]ethanol dihydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

In 1.5 ml of methanol was dissolved 270 mg of 1-(benzo[b]thiophen-5-yl)-2-[(1,4-diformylpiperazin-2-yl)methoxy]ethanol. To the solution was added 1.5 ml of a 5N dry hydrogen chloride-ethanol solution. The resulting mixture was allowed to stand at room temperature overnight. The resulting crystals were collected by filtration, washed with ethanol, and dried to obtain 150 mg of 1-(benzo[b]thiophen-5-yl)-2-[(piperazin-2-yl)methoxy]ethanol dihydrochloride (compound No. 355).

후처리

  1. filtrationThe resulting crystals were collected by filtration
  2. washwashed with ethanol
  3. customdried

출처 및 근거

ORD 기록
ord-f371d22848814e059434d35938ff945b
출처 데이터셋
uspto-grants-1997_03
특허 번호
US05612381

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