Nitric Acid → 2-(3-Methyl-4-nitrophenyl)benzonitrile

HRID 976588

반응식

HRID 976588 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=2[C:10]#[N:11])[CH:5]=[CH:6][CH:7]=1.[N+:16]([O-])([OH:18])=[O:17].S(=O)(=O)(O)O>O>[CH3:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=2[C:10]#[N:11])[CH:5]=[CH:6][C:7]=1[N+:16]([O-:18])=[O:17]

참가 물질

5

반응물 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 13942432-(3-Methylphenyl)benzonitrile

생성물 1

HCID 214689052-(3-Methyl-4-nitrophenyl)benzonitrile

시약·촉매·용매 1

HCID 962Water용매

실험 절차

2-(3-Methylphenyl)benzonitrile (18.1 moles, 3.5 g) was added slowly at -5° C. to a mixture of 10 ml nitric acid and 10 ml sulfuric acid. After 5 minutes, the reaction was diluted with cold water. The solid was collected, dissolved in THP. The solution was dried and concentrated. The solid was recrystallized from ether and hexane to yield 2.45 g of 2-(3-methyl-4-nitrophenyl)benzonitrile. (MS)

후처리

  1. customThe solid was collected
  2. dissolutiondissolved in THP
  3. customThe solution was dried
  4. concentrationconcentrated
  5. customThe solid was recrystallized from ether and hexane

출처 및 근거

ORD 기록
ord-03628136d8bf4f05a010552e7b9d6628
출처 데이터셋
uspto-grants-1997_03
특허 번호
US05612360

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