HCID 21468845, 화합물 → HCID 178442273, 화합물

HRID 976610노트

반응식

HRID 976610 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=2[C:11]#[N:12])[CH:5]=[CH:6][C:7]=1[NH2:8]>C(O)C>[C:11]([C:10]1[CH:13]=[CH:14][CH:15]=[CH:16][C:9]=1[C:4]1[CH:5]=[CH:6][C:7]2[NH:8][C:4]([CH2:3][CH2:2][CH2:7][CH2:6][CH3:5])=[N:1][C:2]=2[CH:3]=1)#[N:12]

참가 물질

3

반응물 1

HCID 21468845HCID 21468845, 화합물

생성물 1

HCID 178442273HCID 178442273, 화합물수율 160.7%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2-(3,4-Diaminophenyl)benzonitrile (4.3 mmoles, 0.9 g) and ethyl hexanoamidate hydrochloride were dissolved in 20 ml ethanol and stirred for 2.5 hours. The solvent was removed in wacuo. The residue was dissolved in ethyl acetate and washed with water, saturated NaHCO3 and brine. The organic phase was dried and concentrated. The residue was chromatographed on silica gel eluted with 1:1 ethylacetate/hexane to yield 1.0 g of 5-(2-Cyanophenyl)-2-pentyl-1H-benzimidazole.

후처리

  1. customThe solvent was removed in wacuo
  2. dissolutionThe residue was dissolved in ethyl acetate
  3. washwashed with water, saturated NaHCO3 and brine
  4. customThe organic phase was dried
  5. concentrationconcentrated
  6. customThe residue was chromatographed on silica gel
  7. washeluted with 1:1 ethylacetate/hexane

출처 및 근거

ORD 기록
ord-b92ee3baa55d4fc488367f2fae8d6580
출처 데이터셋
uspto-grants-1997_03
특허 번호
US05612360

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