Decyl chloroformate → Phthalimide hydrochloride

HRID 976766노트

반응식

HRID 976766 반응식
[Cl:1]C(OCCCCCCCCCC)=O.FC1C=C2C(C(N3CCN(CC[N:33]4[C:37](=[O:38])[C:36]5=[CH:39][CH:40]=[CH:41][CH:42]=[C:35]5[C:34]4=[O:43])CC3)=NN2)=CC=1>CCOCC>[ClH:1].[C:37]1(=[O:38])[NH:33][C:34](=[O:43])[C:35]2=[CH:42][CH:41]=[CH:40][CH:39]=[C:36]12

참가 물질

4

반응물 2

HCID 108727Decyl chloroformateHCID 18467209N-[2-[4-(6-fluoro1H-indazol-3-yl)-1-piperazinyl]ethyl]phthalimide

생성물 1

HCID 22266261Phthalimide hydrochloride

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A mixture of decanyl chloroformate (2.4 g, 11 mmol), and N-[2-[4-(6-fluoro-1H-indazol-3-yl)-1-piperazinyl]ethyl]phthalimide (3.9 g, 10 mmol) was warmed on the steam bath for 15 minutes. The reaction was allowed to cool to ambient temperature, and then ether was added to the residue. The resulting solid was filtered to afford N-2-[4-(1-decanoxy-6-fluoro-1H-indazol-3-yl)-1-piperazinyl]ethyl]phthalimide hydrochloride.

후처리

  1. temperaturewas warmed on the steam bath for 15 minutes
  2. filtrationThe resulting solid was filtered

출처 및 근거

ORD 기록
ord-f6e61114774b4d92a1899af504c612f0
출처 데이터셋
uspto-grants-1997_03
특허 번호
US05612342

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