Decyl chloroformate → Phthalimide hydrochloride

HRID 976898

반응식

HRID 976898 반응식
[Cl:1]C(OCCCCCCCCCC)=O.FC1C=C2C(C(N3CCN(CC[N:33]4[C:37](=[O:38])[C:36]5=[CH:39][CH:40]=[CH:41][CH:42]=[C:35]5[C:34]4=[O:43])CC3)=NN2)=CC=1>CCOCC>[ClH:1].[C:37]1(=[O:38])[NH:33][C:34](=[O:43])[C:35]2=[CH:42][CH:41]=[CH:40][CH:39]=[C:36]12

참가 물질

4

반응물 2

HCID 108727Decyl chloroformateHCID 18467209N-[2-[4-(6-fluoro1H-indazol-3-yl)-1-piperazinyl]ethyl]phthalimide

생성물 1

HCID 22266261Phthalimide hydrochloride

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A mixture of decanyl chloroformate (2.4 g, 11 mmol), and N-[2-[4-(6-fluoro-1H-indazol-3-yl)-1-piperazinyl]ethyl]phthalimide (3.9 g, 10 mmol) was warmed on the steam bath for 15 minutes. The reaction was allowed to cool to ambient temperature, and then ether was added to the residue. The resulting solid was filtered to afford N2-[4-(1 -decanoxy-6-fluoro-1H-indazol-3-yl)-1-piperazinyl]ethyl]phthalimide hydrochloride.

후처리

  1. temperaturewas warmed on the steam bath for 15 minutes
  2. filtrationThe resulting solid was filtered

출처 및 근거

ORD 기록
ord-94eabb6893cd4ead8af84e723c17a62a
출처 데이터셋
uspto-grants-1997_03
특허 번호
US05612343

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