HCID 19965107, 화합물 → HCID 19965122, 화합물

HRID 977102노트

반응식

HRID 977102 반응식
ClC1C=CC(C2SC(C(OCC)=O)=C(C)N=2)=CC=1[N+]([O-])=O.[CH3:22][C:23]1[N:24]=[C:25]([C:33]2[CH:38]=[CH:37][C:36]([N:39]3[CH2:44][CH2:43][O:42][CH2:41][CH2:40]3)=[C:35]([N+:45]([O-:47])=[O:46])[CH:34]=2)[S:26][C:27]=1[C:28]([O:30]CC)=[O:29]>N1CCOCC1>[CH3:22][C:23]1[N:24]=[C:25]([C:33]2[CH:38]=[CH:37][C:36]([N:39]3[CH2:40][CH2:41][O:42][CH2:43][CH2:44]3)=[C:35]([N+:45]([O-:47])=[O:46])[CH:34]=2)[S:26][C:27]=1[C:28]([OH:30])=[O:29]

참가 물질

4

반응물 2

HCID 19965107HCID 19965107, 화합물HCID 19965170Ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate

생성물 1

HCID 19965122HCID 19965122, 화합물수율 71%

시약·촉매·용매 1

HCID 8083Morpholine용매

실험 절차

As described in Example 37, ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate was reacted in morpholine, and the resulting ethyl 4-methyl-2-(4-morpholino-3-nitrophenyl)-5-thiazolecarboxylate was hydrolyzed by a conventional process to give 4-methyl-2(4-morpholino-3-nitrophenyl)-5-thiazolecarboxylic acid (yield: 71%).

출처 및 근거

ORD 기록
ord-42e1f4cbdc364c288e0ef375480f39f4
출처 데이터셋
uspto-grants-1997_03
특허 번호
US05614520

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