Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrogen Sulfide → 2-Amino-5-benzyloxycarbonylamino-2-difluoromethylpentanoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrogen Sulfide | HCID 402 | — |
| 반응물 | Eflornithine | HCID 3009 | — |
| 반응물 | Benzyl chloroformate | HCID 10387 | — |
| 반응물 | Ornithine, 2-(difluoromethyl)-, hydrochloride, hydrate (1:1:1) | HCID 441361 | — |
| 촉매 | Copper carbonate | HCID 14452 | — |
| 촉매 | Copper | HCID 23978 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-Amino-5-benzyloxycarbonylamino-2-difluoromethylpentanoic acid | HCID 11220798 | — |
반응 단계
To a solution of the copper salt of 2-difluoromethyl-2,5-diaminopentanoic acid in water, prepared by reacting 2-difluoromethyl-2,5-diaminopentanoic acid monohydrate hydrochloride (2.4 g) with copper carbonate (6 g), is added slowly at 0° C. with stirring 1.1 g of benzylchloroformate. The reaction mixture is stirred for an additional 3 hours at room temperature after which hydrogen sulfide is passed through the solution until it becomes colorless. The precipitate is filtered off, and the pH of the aqueous solution is adjusted to 6 by the addition of hydrochloric acid. Upon concentration 2-amino-5-benzyloxycarbonylamino-2-difluoromethylpentanoic acid is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05614557 |
| 출처 데이터셋 | uspto-grants-1997_03 |
| ORD ID | ord-51e12d4763664a24a9486d952de7c6c2 |
| 출처 메모 | uspto-grants-1997_03 |