Methyl Acrylate → Methyl 3-(phenylthio)propionate

HRID 978063노트

반응식

HRID 978063 반응식
[C:1]1([SH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CCN(CC)CC.[C:15]([O:19][CH3:20])(=[O:18])[CH:16]=[CH2:17]>C(Cl)Cl>[C:1]1([S:7][CH2:17][CH2:16][C:15]([O:19][CH3:20])=[O:18])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 7294Methyl AcrylateHCID 7969ThiophenolHCID 8471Triethylamine

생성물 1

HCID 350367Methyl 3-(phenylthio)propionate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Thiophenol (440 mg, 4 mmol) and Et3N (70 μl, 0.5 mmol) were dissolved in CH2Cl2 (5 ml). Methyl acrylate (412 mg, 4.8 mmol) was added dropwise. The reaction was exothermic. After stirring at room temperature for 30 minutes, the excess methyl acrylate was removed in vacuo. TLC: silica gel, Et2O-hexane 1:2, UV Rf =0.58. The crude title ester was used without further purification.

후처리

  1. customthe excess methyl acrylate was removed in vacuo
  2. customThe crude title ester was used without further purification

출처 및 근거

ORD 기록
ord-32efc6d138b347daa7d6f31bba07487a
출처 데이터셋
uspto-grants-1987_05
특허 번호
US04663336

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