Ethyl bromoacetate → Ethyl (2-acetyl-3-hydroxyphenoxy)acetate

HRID 978104노트

반응식

HRID 978104 반응식
[CH3:1][C:2]([C:4]1[C:5]([OH:11])=[CH:6][CH:7]=[CH:8][C:9]=1[OH:10])=[O:3].Br[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:17]([O:16][C:14](=[O:15])[CH2:13][O:11][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]([OH:10])[C:4]=1[C:2](=[O:3])[CH3:1])[CH3:18]

참가 물질

5

반응물 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 696872',6'-Dihydroxyacetophenone

생성물 1

HCID 4673143Ethyl (2-acetyl-3-hydroxyphenoxy)acetate

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 2,6-dihydroxyacetophenone (40 g), ethyl bromoacetate (48 g) and potassium carbonate (58 g) in acetone (500 ml) was refluxed for 3 hours. The mixture was cooled and filtered. The solution was evaporated to dryness and the crude solid extracted with boiling hexane. Upon cooling, the title compound was obtained.

후처리

  1. temperaturewas refluxed for 3 hours
  2. temperatureThe mixture was cooled
  3. filtrationfiltered
  4. customThe solution was evaporated to dryness
  5. extractionthe crude solid extracted with boiling hexane
  6. temperatureUpon cooling

출처 및 근거

ORD 기록
ord-5daafc56e4054350848aa44c9f5eec5d
출처 데이터셋
uspto-grants-1987_05
특허 번호
US04663347

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