Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,2,3,4-Tetrahydroquinoline → 10-methyl-7-(4-methyl-1-piperazinyl)-2,3-dihydro-1H-quino[1,8-ab][1,5]benzodiazepine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,2,3,4-Tetrahydroquinoline | HCID 69460 | — |
| 반응물 | 4-Fluoro-3-nitrotoluene | HCID 136287 | — |
| 반응물 | N-[2-(2,3-dihydro-1H-indol-1-yl)-5-fluorophenyl]-4-methyl-1-piperazine carboxamide maleate | HCID 70406853 | — |
| 생성물 | 10-methyl-7-(4-methyl-1-piperazinyl)-2,3-dihydro-1H-quino[1,8-ab][1,5]benzodiazepine | HCID 20129109 | — |
| 생성물 | 1-(4-Methyl-2-nitrophenyl)-1,2,3,4-tetrahydroquinoline | HCID 21297653 | — |
| 생성물 | 2-[3,4-Dihydro-1(2H)-quinolinyl]-5-methylaniline | HCID 21297677 | — |
반응 단계
Starting with 1,2,3,4-tetrahydroquinoline and 2-fluoro-5-methylnitrobenzene and following the steps of 1a to 1f of Example 2, one may obtain, in sequence, 1-(4-methyl-2-nitrophenyl)-1,2,3,4-tetrahydroquinoline, 1-(2-amino-4-methylphenyl)-1,2,3,4-tetrahydroquinone, 1-(2-amino-4-methylphenyl)-1,2,3,4-tetrahydroquinoline, N-[2-{1-(5-methylphenyl)-1,2,3,4-tetrahydroquinolin-1-yl}]-4-methyl-1-piperazine carboxamide, and 10-methyl-7-(4-methyl-1-piperazinyl)-2,3-dihydro-1H-quino[1,8-ab][1,5]benzodiazepine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04663453 |
| 출처 데이터셋 | uspto-grants-1987_05 |
| ORD ID | ord-529ac75be2f54f869bb64c1964fcfd9f |
| 출처 메모 | uspto-grants-1987_05 |