Trimethylamine → (-)-Carnitine

HRID 978325노트

반응식

C[O:2][C:3](=[O:9])[CH2:4][C@@H:5]([OH:8])[CH2:6]Cl.[CH3:10][N:11]([CH3:13])[CH3:12]>>[OH:8][C@H:5]([CH2:4][C:3](=[O:9])[O-:2])[CH2:6][N+:11]([CH3:13])([CH3:12])[CH3:10]

참가 물질

반응물 2

HCID 1146Trimethylamine

HCID 10920707Methyl (R)-4-Chloro-3-hydroxybutyrate

생성물 1

HCID 10917(-)-Carnitine수율 32%

실험 절차

An amount of 100 g of (3R)-4-chloro-3-hydroxybutyrylamide of L-tyrosine methylester is submitted to methanolysis under the same operating conditions as reported in Example 2. An amount is obtained of 20 g (70%) of (3R)-4-chloro-3-hydroxybutyric acid methylester with [α]D20 =-23° (c=1.5 in CHCL3). (3R)-4-Chloro-3-hydroxybutyric acid methylester is treated with trimethylamine and L-carnitine is obtained (yield 32%).

출처 및 근거

ORD 기록: ord-baf89e5784a34c4194ea2a8d0eefe502
출처 데이터셋: uspto-grants-1987_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04664852

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