Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Nitrophenol → benzyloxycarbonyl-L-lysine amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Nitrophenol | HCID 980 | — |
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | N-alpha-Benzyloxycarbonyl-L-lysine | HCID 75172 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | benzyloxycarbonyl-L-lysine amide | HCID 7020264 | — |
반응 단계
Na -t-butyloxycarbonyl-Ne -benzyloxycarbonyl-L-lysine was dissolved in ethyl acetate and esterified with p-nitrophenol using dicyclohexylcarbodiimide as a coupling agent. Sodium bicarbonate (10%) was added and the product extracted into the organic layer and crystallized from solution, then added to aqueous ammonium hydroxide to form Na -t-butyloxycarbonyl-Ne -benzyloxycarbonyl-L-lysine amide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04665054 |
| 출처 데이터셋 | uspto-grants-1987_05 |
| ORD ID | ord-14bbdd6d54904e618df25400db7d786c |
| 출처 메모 | uspto-grants-1987_05 |