4-Toluenesulfonyl chloride → 11-Phenylundecanol tosylate

HRID 978677노트

반응식

HRID 978677 반응식
[C:1]1([CH3:11])[CH:6]=[CH:5][C:4]([S:7](Cl)(=[O:9])=[O:8])=[CH:3][CH:2]=1.[C:12]1([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][OH:29])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>N1C=CC=CC=1>[S:7]([O:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)([C:4]1[CH:5]=[CH:6][C:1]([CH3:11])=[CH:2][CH:3]=1)(=[O:9])=[O:8]

참가 물질

4

반응물 2

HCID 73974-Toluenesulfonyl chlorideHCID 11651716Benzeneundecanol

생성물 1

HCID 5393925311-Phenylundecanol tosylate

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

4-Toluenesulphonyl chloride (2.6 g) was added in portions to a stirred solution of the product of step (a) (2.9 g) in pyridine (10 ml) at 0° C. The solution was stirred for 16 hours at 0°-5° C. then poured onto ice-hydrochloric acid and extracted with ether. The extract was washed with sodium bicarbonate and sodium chloride solutions, dried and evaporated. The residue was chromatographed on silica gel eluting with 1:1 dichloromethane:hexane to give the title compound as a colourless oil.

후처리

  1. additionthen poured onto ice-hydrochloric acid
  2. extractionextracted with ether
  3. washThe extract was washed with sodium bicarbonate and sodium chloride solutions
  4. customdried
  5. customevaporated
  6. customThe residue was chromatographed on silica gel eluting with 1:1 dichloromethane

출처 및 근거

ORD 기록
ord-c6796cba41954d6eb4b6efc77229340b
출처 데이터셋
uspto-grants-1987_05
특허 번호
US04665189

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