Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Toluene → Gemfibrozil
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | 2-Methylpropyl 5-chloro-2,2-dimethylpentanoate | HCID 13913710 | — |
| 반응물 | Sodium 2,5-dimethylphenolate | HCID 23672785 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | Gemfibrozil | HCID 3463 | 80% |
반응 단계
subsequently reacting said 2-methylpropyl 5-chloro-2,2-dimethylpentanoate with sodium 2,5-dimethylphenolate under reflux in a solvent comprising a mixture of from 10 parts (V/V) toluene/1 part (V/V) dimethylsulfoxide to 5 parts (V/V) toluene/1 part (V/V) dimethylsulfoxide, hydrolyzing the resulting ester, and thereafter acidifying the mixture and isolating 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid;
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04665226 |
| 출처 데이터셋 | uspto-grants-1987_05 |
| ORD ID | ord-236b92105dd24bb1a6f646a20ccc4c94 |
| 출처 메모 | uspto-grants-1987_05 |