HCID 86740397, 화합물 → HCID 86740398, 화합물

HRID 978849노트

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HRID 978849 반응식
[C:1]([O:4][C@@H:5]1[N:8]([S:9]([O-:12])(=[O:11])=[O:10])[C:7](=[O:13])[C@H:6]1[NH:14][C:15](=[O:32])[C:16]([C:22]1[N:23]=[C:24]([NH:27]C(=O)CCl)[S:25][CH:26]=1)=[N:17][O:18][CH:19]([CH3:21])[CH3:20])(=[O:3])[CH3:2].[Na+:33].CSC(=S)N.[Na]>O>[C:1]([O:4][C@@H:5]1[N:8]([S:9]([O-:12])(=[O:11])=[O:10])[C:7](=[O:13])[C@H:6]1[NH:14][C:15](=[O:32])[C:16]([C:22]1[N:23]=[C:24]([NH2:27])[S:25][CH:26]=1)=[N:17][O:18][CH:19]([CH3:21])[CH3:20])(=[O:3])[CH3:2].[Na+:33]

참가 물질

4

반응물 2

HCID 86740397HCID 86740397, 화합물HCID 86740399HCID 86740399, 화합물

생성물 1

HCID 86740398HCID 86740398, 화합물수율 71.4%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of 0.250 g sodium (3S,4S)-4-acetoxy-3-[2-(2-chloroacetamidothiazol-4-yl)-2-isopropoxyiminoacetamido]-2-oxoazetidine-1-sulfonate in 4 ml of water is added 73 mg of sodium monomethyldithiocarbamate under ice-cooling and the mixture is stirred at room temperature for one hour. The insolubles are filtered off and the filtrate is purified on a column of XAD-II. The above procedure gives 0.153 g of sodium (3S,4S)-4-acetoxy-3-[2-(2-aminothiazol-4-yl)-2-isopropoxyiminoacetamido]-2-oxoazetidine-1-sulfonate.

후처리

  1. temperaturecooling
  2. filtrationThe insolubles are filtered off
  3. customthe filtrate is purified on a column of XAD-II

출처 및 근거

ORD 기록
ord-3dae7eb1932c4b259d3bb92c7e2f764c
출처 데이터셋
uspto-grants-1987_05
특허 번호
US04665067

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