Water → 10-acetyl-4-chloro-3-hydroxy-10H-phenothiazine

HRID 979083노트

반응식

HRID 979083 반응식
[Cl:1][C:2]1[C:15]2[S:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[NH:7][C:6]=2[CH:5]=[CH:4][C:3]=1[OH:16].[C:17](Cl)(=[O:19])[CH3:18].C(OCC)(=O)C.O>CN(C=O)C>[C:17]([N:7]1[C:6]2[CH:5]=[CH:4][C:3]([OH:16])=[C:2]([Cl:1])[C:15]=2[S:14][C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)(=[O:19])[CH3:18]

참가 물질

6

반응물 4

HCID 962WaterHCID 6367Acetyl chlorideHCID 8857Ethyl AcetateHCID 98814184-chloro-3-hydroxy-10H-phenothiazine

생성물 1

HCID 1388203310-acetyl-4-chloro-3-hydroxy-10H-phenothiazine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 4-chloro-3-hydroxyphenothiazine (2.2 g) in DMF (10 ml) was added 10 ml of acetyl chloride. The reaction mixture was stirred at ambient temperature for 1 hour. Ethyl acetate was then added, followed by ice and H2O. The organic layer was separated, dried and evaporated. The resulting residue was purified by chromatography on silica gel to give 1.4 g of 10-acetyl-4-chloro-3-hydroxy-10H-phenothiazine (m.p. 214° C.).

후처리

  1. customThe organic layer was separated
  2. customdried
  3. customevaporated
  4. customThe resulting residue was purified by chromatography on silica gel

출처 및 근거

ORD 기록
ord-538072a4fc7c40ada44760109d8539a9
출처 데이터셋
uspto-grants-1987_05
특허 번호
US04666907

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