Piperidine → Acridine, 3,6-bis(2-(1-piperidinyl)ethoxy)-

HRID 979104노트

반응식

HRID 979104 반응식
Cl.Cl[CH2:3][CH2:4][O:5][C:6]1[CH:7]=[CH:8][C:9]2[C:18]([CH:19]=1)=[N:17][C:16]1[C:11](=[CH:12][CH:13]=[C:14]([O:20][CH2:21][CH2:22]Cl)[CH:15]=1)[CH:10]=2.[NH:24]1[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1>>[N:24]1([CH2:3][CH2:4][O:5][C:6]2[CH:7]=[CH:8][C:9]3[C:18]([CH:19]=2)=[N:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:20][CH2:21][CH2:22][N:17]4[CH2:18][CH2:9][CH2:10][CH2:11][CH2:16]4)[CH:15]=2)[CH:10]=3)[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1

참가 물질

3

반응물 2

HCID 8082PiperidineHCID 201846653,6-Bis(2-chloroethoxy)acridine hydrochloride

생성물 1

HCID 133712Acridine, 3,6-bis(2-(1-piperidinyl)ethoxy)-

실험 절차

A suspension of 3,6-bis(2-chloroethoxy)acridine hydrochloride in piperidine was heated in a steel bomb at 80° C. for 24 hours. The excess piperidine was removed in vacuo and the residual solution was washed twice with 30 ml portions of saturated aqueous sodium bicarbonate and filtered. The filtrate was evaporated to a residue, giving 3,6-bis(2-piperidinoethoxy)acridine as yellow crystals, mp 129°-130° C.

후처리

  1. customThe excess piperidine was removed in vacuo
  2. washthe residual solution was washed twice with 30 ml portions of saturated aqueous sodium bicarbonate
  3. filtrationfiltered
  4. customThe filtrate was evaporated to a residue

출처 및 근거

ORD 기록
ord-672f57c7110b442d935da12e8fcfa842
출처 데이터셋
uspto-grants-1987_05
특허 번호
US04666917

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