Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Butyl 4-aminobenzoate → Ethyl 1,6-dihydro-2-(4-butoxycarbonylanilino)-6-oxo-5-pyrimidinecarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Butyl 4-aminobenzoate | HCID 2482 | — |
| 반응물 | Ethyl 4-hydroxy-2-(methylsulfanyl)-5-pyrimidinecarboxylate | HCID 239049 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Ethyl 1,6-dihydro-2-(4-butoxycarbonylanilino)-6-oxo-5-pyrimidinecarboxylate | HCID 13562812 | 41.7% |
반응 단계
Ethyl 1,6-dihydro-2-methylthio-6-oxo-5-pyrimidinecarboxylate (10 g) and butyl -4-aminobenzoate (10.8 g) are added to ethanol (100 ml), and the mixture is refluxed with stirring for 48 hours. After cooling, the precipitate is collected by filtration and recrystallized from a mixture of DMF and water to give ethyl 1,6-dihydro-2-(4-butoxycarbonylanilino)-6-oxo-5-pyrimidinecarboxylate (7.0 g). M.p. 281°-283° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04666915 |
| 출처 데이터셋 | uspto-grants-1987_05 |
| ORD ID | ord-af91b5896fc74264967fab2191b6c057 |
| 출처 메모 | uspto-grants-1987_05 |