Methyl Acrylate → HCID 21621270, 화합물

HRID 979258노트

반응식

HRID 979258 반응식
[CH2:1]([N:8]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[OH:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:17]([O:21][CH3:22])(=[O:20])[CH:18]=[CH2:19].CC(C)([O-])C.[K+]>O1CCCC1>[CH3:22][O:21][C:17](=[O:20])[CH2:18][CH2:19][O:9][N:8]([CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

5

반응물 3

HCID 7294Methyl AcrylateHCID 69297DibenzylhydroxylamineHCID 23665647Potassium tert-butoxide

생성물 1

HCID 21621270HCID 21621270, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 42.6 g of N,N-dibenzylhydroxylamine, 25.8 g of methyl acrylate and 2.0 g of potassium-tert-butoxide in 200 ml of tetrahydrofuran is heated under reflux for 12 hours under N2. The crude reaction mixture is concentrated under reduced pressure and the residue is partitioned between water and ether. The orcanic layer is washed with water, saturated NaHSO4 solution and brine, dried (MgSO4) and then evaporated under reduced pressure to give the title compound as an oil.

후처리

  1. temperatureunder reflux for 12 hours under N2
  2. customThe crude reaction mixture
  3. concentrationis concentrated under reduced pressure
  4. customthe residue is partitioned between water and ether
  5. washThe orcanic layer is washed with water, saturated NaHSO4 solution and brine
  6. dry with materialdried (MgSO4)
  7. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-55086bda318e429d99808034e1a1d662
출처 데이터셋
uspto-grants-1987_05
특허 번호
US04666962

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