Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Nitrobenzenesulfonic acid → 6-[4-(Imidazol-1-yl-methyl)-thien-2-yl]-3(2H)-pyridazinone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Nitrobenzenesulfonic acid | HCID 7387 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 반응물 | 4.5-dihydro-6-[4-(imidazol-1-yl-methyl)-thien-2-yl]-3(2H)-pyridazinone | HCID 13318704 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 6-[4-(Imidazol-1-yl-methyl)-thien-2-yl]-3(2H)-pyridazinone | HCID 13370246 | — |
반응 단계
Analoguous to Example 4, the reaction is carried out with 3 g of 4.5-dihydro-6-[4-(imidazol-1-yl-methyl)-thien-2-yl]-3(2H)-pyridazinone (prepared analoguous to Example 3, m.p. 178° to 179° C.), 2.9 g of the sodium salt of 3-nitrobenzenesulfonic acid and 2 g of sodium hydroxide in 40 ml of water. The reaction mixture is neutralized by the addition of 2.5 ml of acetic acid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04667033 |
| 출처 데이터셋 | uspto-grants-1987_05 |
| ORD ID | ord-c3b3db63f4814e29a542ad232f754e4d |
| 출처 메모 | uspto-grants-1987_05 |