Triethylamine → HCID 13657069, 화합물

HRID 979325

반응식

HRID 979325 반응식
[Cl:1][C:2]1[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[CH:17][C:3]=1[O:4][C:5]1[CH:6]=[CH:7][C:8]([N+:14]([O-:16])=[O:15])=[C:9]([CH:13]=1)[C:10](Cl)=[O:11].[C:25]([O:35][CH2:36][CH3:37])(=[O:34])[CH:26]([CH2:28][C:29]([O:31][CH2:32][CH3:33])=[O:30])[OH:27].C(N(CC)CC)C>CC(C)=O.O>[Cl:1][C:2]1[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[CH:17][C:3]=1[O:4][C:5]1[CH:6]=[CH:7][C:8]([N+:14]([O-:16])=[O:15])=[C:9]([CH:13]=1)[C:10]([O:27][CH:26]([C:25]([O:35][CH2:36][CH3:37])=[O:34])[CH2:28][C:29]([O:31][CH2:32][CH3:33])=[O:30])=[O:11]

참가 물질

6

반응물 3

HCID 8471TriethylamineHCID 24197Diethyl malateHCID 30177655-(2-Chloro-4-(trifluoromethyl)phenoxy)-2-nitrobenzoyl chloride

생성물 1

HCID 13657069HCID 13657069, 화합물수율 66.7%

시약·촉매·용매 2

HCID 180Acetone용매3회HCID 962Water용매

실험 절차

To a stirred solution of 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoyl chloride (3.8 g, 0.01 mole) in acetone (10 ml) was successively added diethyl DL malate (1.9 g, 0.01 mole) in acetone (10 ml) and triethylamine (1.01 g, 0.01 mole) in acetone (5 ml). A white precipitate quickly formed. The reaction was heated to reflux for 24 hours. Upon cooling, the reaction was poured in water (75 ml) and extracted twice with methylene chloride (25 ml @). The combined organic extracts were successively washed with 5% sodium hydroxide and brine solutions. The dried solution was stripped of solvent to give 3.56 g of an amber oil.

후처리

  1. customA white precipitate quickly formed
  2. temperatureThe reaction was heated
  3. temperatureto reflux for 24 hours
  4. temperatureUpon cooling
  5. extractionextracted twice with methylene chloride (25 ml @)
  6. washThe combined organic extracts were successively washed with 5% sodium hydroxide and brine solutions

출처 및 근거

ORD 기록
ord-c3b3c7d9e0284cfe931dcb2aa93c815f
출처 데이터셋
uspto-grants-1987_05
특허 번호
US04667052

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