1H-1,2,4-Triazole → Tebuconazole

HRID 979451

반응식

HRID 979451 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]2([C:13]([CH3:16])([CH3:15])[CH3:14])[CH2:12][O:11]2)=[CH:4][CH:3]=1.[NH:17]1[CH:21]=[N:20][CH:19]=[N:18]1>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([CH2:12][N:17]2[CH:21]=[N:20][CH:19]=[N:18]2)([OH:11])[C:13]([CH3:16])([CH3:15])[CH3:14])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 92571H-1,2,4-TriazoleHCID 946842-tert-Butyl-2-(2-(4-chlorophenyl)ethyl)oxirane

생성물 1

HCID 86102Tebuconazole수율 53.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 17.9 g (0.075 mole) of 2-(4-chlorophenylethyl)-2-tert.-butyloxirane and 6.9 g (0.1 mole) of 1,2,4-triazole in 30 ml of ethanol in a sealed tube is heated at 150° C. for 20 hours. The tube is allowed to cool and the reaction solution is evaporated. The residue is dissolved in ether, washed three times with water and once with sodium chloride solution, dried over sodium sulphate and evaporated. The residue is chromatographed over a column of silican gel (mobile phase: dichloroethane/ethyl acetate 1:1). 12.3 g (53.2% of theory) of 1-(4-chlorophenyl)-4,4-dimethyl-3-(1,2,4-triazol-1-yl-methyl)-3-pentanol are obtained as a viscous oil.

후처리

  1. temperatureto cool
  2. customthe reaction solution is evaporated
  3. dissolutionThe residue is dissolved in ether
  4. washwashed three times with water
  5. dry with materialonce with sodium chloride solution, dried over sodium sulphate
  6. customevaporated
  7. customThe residue is chromatographed over a column of silican gel (mobile phase: dichloroethane/ethyl acetate 1:1)

출처 및 근거

ORD 기록
ord-7450237c8f7f43f99617dae5adba092e
출처 데이터셋
uspto-grants-1987_05
특허 번호
US04668660

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