Anthranilic Acid → Methyl 2-{[(2-methoxyphenyl)acetyl]amino}benzoate

HRID 979493

반응식

HRID 979493 반응식
[C:1](=O)([O-])[O-].[K+].[K+].[C:7]([OH:16])(=[O:15])[C:8]1[C:9](=[CH:11][CH:12]=[CH:13][CH:14]=1)[NH2:10].[CH3:17][O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[CH2:25][C:26](Cl)=[O:27]>CC(C)=O>[CH3:1][O:15][C:7](=[O:16])[C:8]1[C:9](=[CH:11][CH:12]=[CH:13][CH:14]=1)[NH:10][C:26](=[O:27])[CH2:25][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=1[O:18][CH3:17]

참가 물질

5

반응물 3

HCID 227Anthranilic AcidHCID 11430Potassium CarbonateHCID 1795022-(2-Methoxyphenyl)acetyl chloride

생성물 1

HCID 717617Methyl 2-{[(2-methoxyphenyl)acetyl]amino}benzoate수율 78%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a mixed solution of acetone (300 ml) and a 6% aqueous potassium carbonate solution (200 ml) there were added 10.2 g (67 mmol) of methyl ester of anthranilic acid. 12.5 g (67 mmol) of 2-Methoxyphenylacetic acid chloride were added dropwise under cooling thereto and the resulting reaction mixture was stirred at room temperature for 4 hours. The resulting precipitates were collected by filtration to obtain 15.7 g (yield 78%) of N-(2-methoxyphenylacetyl)-anthranilic acid methyl ester.

후처리

  1. temperatureunder cooling
  2. customthe resulting reaction mixture
  3. customThe resulting precipitates
  4. filtrationwere collected by filtration

출처 및 근거

ORD 기록
ord-3af38ca4d1344b39877c57baa2b4fefc
출처 데이터셋
uspto-grants-1987_05
특허 번호
US04668682

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