Sodium Methoxide → 1-[4-(2-Methoxyethoxy)phenyl]methanamine

HRID 979786노트

반응식

HRID 979786 반응식
Cl[CH2:2][CH2:3][O:4][C:5]1[CH:12]=[CH:11][C:8]([CH2:9][NH2:10])=[CH:7][CH:6]=1.[CH3:13][O-:14].[Na+]>C1(C)C=CC=CC=1.CO>[CH3:13][O:14][CH2:2][CH2:3][O:4][C:5]1[CH:12]=[CH:11][C:8]([CH2:9][NH2:10])=[CH:7][CH:6]=1

참가 물질

5

반응물 2

HCID 10942334Sodium MethoxideHCID 202228754-(2-Chloroethoxy)benzylamine

생성물 1

HCID 202228351-[4-(2-Methoxyethoxy)phenyl]methanamine

시약·촉매·용매 2

HCID 887Methanol용매HCID 1140Toluene용매

실험 절차

4-(2-Chloroethoxy)benzylamine (2.0 g; 0,11 mol) was dissolved in anhydrous toluene (50 ml). The reaction mixture was ice-cooled and sodium methoxide (0.59 g; 0.011 mol) dissolved in methanol (5 ml) was added thereto. When the addition was complete the mixture was left to stand for 2 hours at room temperature and filtered. Solvent was evaporated from the filtrate, to give an oily residue of good purity.

후처리

  1. temperaturecooled
  2. additionwas added
  3. additionWhen the addition
  4. waitwas left
  5. filtrationfiltered
  6. customSolvent was evaporated from the filtrate
  7. customto give an oily residue of good purity

출처 및 근거

ORD 기록
ord-af266a91e9b84dd09eeb033e3f4830d6
출처 데이터셋
uspto-grants-1987_01
특허 번호
US04634701

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