HCID 20222962, 화합물 → N-(5,6,7,8-Tetrahydro-4-methyl-5-oxo-2-naphthalenyl)acetamide
반응식
[C:1]([NH:4][C:5]1[CH:6]=[C:7]([CH2:12][CH2:13][CH2:14][C:15]([OH:17])=O)[CH:8]=[C:9]([CH3:11])[CH:10]=1)(=[O:3])[CH3:2]>C[Si](OP(=O)=O)(C)C>[C:1]([NH:4][C:5]1[CH:6]=[C:7]2[C:8](=[C:9]([CH3:11])[CH:10]=1)[C:15](=[O:17])[CH2:14][CH2:13][CH2:12]2)(=[O:3])[CH3:2]참가 물질
3
반응 조건
- 온도
- 0 °C
실험 절차
The product from Example 129 (3 g) was treated with a solution of trimethylsilyl polyphosphate (PPSE) (50 ml in o-dichlorobenzene) at 100° C. for 10 minutes. The reaction was cooled to 0° C., quenched with 2NHCl and extracted with methylene chloride. The organic layer was separated, dried and evaporated to one-half the volume and purified on a small bed of silica gel. The desired tetralone was obtained in 40% yield. m.p.