HCID 13755489, 화합물 → 1-(4-Oxocyclohexyl)imidazolidin-2-one

HRID 979903노트

반응식

HRID 979903 반응식
N[CH:2]1[CH2:7][CH2:6][CH:5]([N:8]2[CH2:12][CH2:11][NH:10][C:9]2=[O:13])[CH2:4][CH2:3]1.Cl[O-:15].[K+]>[Cl-].C([N+](CCCC)(CCCC)CCCC)C1C=CC=CC=1.C(OCC)(=O)C>[O:15]=[C:2]1[CH2:7][CH2:6][CH:5]([N:8]2[CH2:12][CH2:11][NH:10][C:9]2=[O:13])[CH2:4][CH2:3]1

참가 물질

5

반응물 2

HCID 13755489HCID 13755489, 화합물HCID 23665762Potassium hypochlorite

생성물 1

HCID 202230821-(4-Oxocyclohexyl)imidazolidin-2-one

시약·촉매·용매 2

HCID 159952Benzyltributylammonium chloride촉매HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 18.3 g of 1-(4-aminocyclohexyl)-2-imidazolidinone as a mixture of cis and trans isomers, 2.0 g of benzyltributylammonium chloride, 250 ml of ethyl acetate and 360 ml of an aqueous 10% potassium hypochlorite solution [according to methodology as described by C. A. Meyers, J. Org. Chem. 26, 1046 (1961)] is stirred at room temperature for 11/2 hours. The organic layer is separated and the aqueous layer is extracted with ethyl acetate. The pooled organic phases are washed with water, sodium bicarbonate solution and dilute hydrochloric acid, then dried and evaporated to dryness to yield 1-(4-oxocyclohexyl)-2-imidazolidinone.

후처리

  1. customThe organic layer is separated
  2. extractionthe aqueous layer is extracted with ethyl acetate
  3. washThe pooled organic phases are washed with water, sodium bicarbonate solution and dilute hydrochloric acid
  4. customdried
  5. customevaporated to dryness

출처 및 근거

ORD 기록
ord-9fd8a531d3e44da2bc425bc004f22739
출처 데이터셋
uspto-grants-1987_01
특허 번호
US04634713

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