Sodium Carbonate → HCID 178433270, 화합물

HRID 979928노트

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HRID 979928 반응식
Cl.Cl[CH2:3][C:4]1[NH:8][CH:7]=[N:6][C:5]=1[CH3:9].[O:10]1[CH:14]=[CH:13][CH:12]=[C:11]1[CH2:15][N:16]1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[N:18]=[C:17]1[NH:25][CH:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1.C(=O)([O-])[O-].[Na+].[Na+]>CN(C)C=O>[O:10]1[CH:14]=[CH:13][CH:12]=[C:11]1[CH2:15][N:16]1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[N:18]=[C:17]1[NH:25][CH:26]1[CH2:27][CH2:28][N:29]([CH2:3][C:4]2[NH:8][CH:7]=[N:6][C:5]=2[CH3:9])[CH2:30][CH2:31]1

참가 물질

5

반응물 3

HCID 10340Sodium CarbonateHCID 135879951-(2-furanylmethyl)-N-(4-piperidinyl)-1H-benzimidazol-2-amineHCID 178433265HCID 178433265, 화합물

생성물 1

HCID 178433270HCID 178433270, 화합물수율 60.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
70 °C

실험 절차

A mixture of 3.4 parts of 5-(chloromethyl)-4-methyl-1H-imidazole monohydrochloride, 6 parts of 1-(2-furanylmethyl)-N-(4-piperidinyl)-1H-benzimidazol-2-amine, 4.25 parts of sodium carbonate and 135 parts of N,N-dimethylformamide was stirred and heated for 3 hours at 70° C. The reaction mixture was poured onto water and the product was extracted with trichloromethane. The extract was dried, filtered and evaporated. The residue was crystallized from a mixture of acetonitrile and methanol, yielding 4.7 parts (60.2%) of 1-(2-furanylmethyl)-N-[1-[(4-methyl-1H-imidazol-5-yl)methyl]-4-piperidinyl]-1H-benzimidazol-2-amine; mp. 242.1° C. (compound 1).

후처리

  1. additionThe reaction mixture was poured onto water
  2. extractionthe product was extracted with trichloromethane
  3. customThe extract was dried
  4. filtrationfiltered
  5. customevaporated
  6. customThe residue was crystallized from a mixture of acetonitrile and methanol

출처 및 근거

ORD 기록
ord-2a73bbde20974649b7506ceaa3b5686c
출처 데이터셋
uspto-grants-1987_01
특허 번호
US04634704

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