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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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N-(1-Carbobenzyloxy-5-phthalimidopentyl)-alpha-azaalanyl-(L)-proline-t-butyl ester → N-(1-Carboxy-5-phthalimidopentyl)-alpha-azaalanyl-(L)-proline-t-butyl ester

HRID 979959
노트
인쇄 미리보기

반응식

HRID 979959 반응식
[C:1]([O:5][C:6](=[O:43])[C@@H:7]1[CH2:11][CH2:10][CH2:9][N:8]1[C:12](=[O:42])[N:13]([CH3:41])[NH:14][CH:15]([C:31]([O:33]CC1C=CC=CC=1)=[O:32])[CH2:16][CH2:17][CH2:18][CH2:19][N:20]1[C:24](=[O:25])[C:23]2=[CH:26][CH:27]=[CH:28][CH:29]=[C:22]2[C:21]1=[O:30])([CH3:4])([CH3:3])[CH3:2]>C(OCC)(=O)C.C(O)(=O)C.[Pd]>[C:1]([O:5][C:6](=[O:43])[C@@H:7]1[CH2:11][CH2:10][CH2:9][N:8]1[C:12](=[O:42])[N:13]([CH3:41])[NH:14][CH:15]([C:31]([OH:33])=[O:32])[CH2:16][CH2:17][CH2:18][CH2:19][N:20]1[C:24](=[O:25])[C:23]2=[CH:26][CH:27]=[CH:28][CH:29]=[C:22]2[C:21]1=[O:30])([CH3:4])([CH3:2])[CH3:3]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 1

HCID 18606049N-(1-Carbobenzyloxy-5-phthalimidopentyl)-alpha-azaalanyl-(L)-proline-t-butyl ester

생성물 1

HCID 18606065N-(1-Carboxy-5-phthalimidopentyl)-alpha-azaalanyl-(L)-proline-t-butyl ester수율 96.7%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 176Acetic Acid용매HCID 8857Ethyl Acetate용매

실험 절차

A solution of azapeptide ester 24 (0.402 g; 0.679 mmol) in ethyl acetate (5 ml) and acetic acid (0.2 ml) was hydrogenated with 110 mg of 10% Pd C for 18 hours. Filtration of catalyst and removal of solvent gave azapeptide 25 as a white foam (0.330 g). TLC (silica gel; EPAW 20:5:1:1) Rf=0.7. MS m/e 574 (M+, monotrimethylsilyl). NMR (CDCl3): δ1.42 (9H.s); 1.5-2.1 (10H,m); 3.00 (3H,s); 3.4-3.8 (5H,m); 4.3-4.6 (1H,m); 7.6-7.8 (4H,m); 7.8-8.0 (1H, broad).

후처리

  1. filtrationFiltration of catalyst and removal of solvent

출처 및 근거

ORD 기록
ord-bbccc7cf8b4946ab938246fc04b88db1
출처 데이터셋
uspto-grants-1987_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04634715

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