Potassium Hydroxide → 3-Methylflavone-8-carboxylic acid

HRID 979992노트

반응식

HRID 979992 반응식
[CH3:1][C:2]1[C:11](=[O:12])[C:10]2[C:5](=[C:6]([C:13]([O:15]C)=[O:14])[CH:7]=[CH:8][CH:9]=2)[O:4][C:3]=1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[OH-].[K+]>CO>[CH3:1][C:2]1[C:11](=[O:12])[C:10]2[C:5](=[C:6]([C:13]([OH:15])=[O:14])[CH:7]=[CH:8][CH:9]=2)[O:4][C:3]=1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 7582698Methyl 3-methylflavone-8-carboxylate

생성물 1

HCID 770163-Methylflavone-8-carboxylic acid수율 97.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A 29.4 g (0.10 mole) quantity of methyl 3-methylflavone-8-carboxylate was added to 200 ml of a solution of 0.5N--KOH in methanol. The mixture was refluxed with heating for 3 hours and the solvent was removed by distillation. To the residue was added 300 ml of water to dissolve the residue in water and the solution was subjected to filtration. The filtrate was neutralized with dilute hydrochloric acid to give 27.3 g (97.5%) of 3-methylflavone-8-carboxylic acid, M.P. 229° to 231.5° C.

후처리

  1. temperatureThe mixture was refluxed
  2. temperaturewith heating for 3 hours
  3. customthe solvent was removed by distillation
  4. additionTo the residue was added 300 ml of water
  5. dissolutionto dissolve the residue in water
  6. filtrationthe solution was subjected to filtration

출처 및 근거

ORD 기록
ord-6b3791617d64429aa20603dd4c29522d
출처 데이터셋
uspto-grants-1987_01
특허 번호
US04634768

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