Diethyl Ether → HCID 20159920, 화합물

HRID 980009노트

반응식

HRID 980009 반응식
C(OC([NH:8][CH2:9][CH:10]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:11][CH2:12][NH:13][S:14]([C:17]1[C:18]2[CH:19]=[CH:20][N:21]=[CH:22][C:23]=2[CH:24]=[CH:25][CH:26]=1)(=[O:16])=[O:15])=O)(C)(C)C.C(OCC)C>FC(F)(F)C(O)=O>[NH2:8][CH2:9][CH:10]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:11][CH2:12][NH:13][S:14]([C:17]1[C:18]2[CH:19]=[CH:20][N:21]=[CH:22][C:23]=2[CH:24]=[CH:25][CH:26]=1)(=[O:16])=[O:15]

참가 물질

4

반응물 2

HCID 3283Diethyl EtherHCID 20159947HCID 20159947, 화합물

생성물 1

HCID 20159920HCID 20159920, 화합물수율 97%

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

In 30 ml of trifluoroacetic acid was dissolved 6.0 g of N-(4-t-butoxycarbonylamino-3-phenylbutyl)-5-isoquinolinesulfonamide, and left at a temperature of 20° C.~25° C. for 30 minutes. The mixrure was condensed under reduced pressure. To the reaction solution was added ethyl ether, and the crystals precipitated were separated by filtration. The crystals thus obtained were washed with ethylether to give 4.54 g of N-(4-amino-3-phenylbutyl)-5-isoquinolinesulfonamide in a yield of 97%.

후처리

  1. customcondensed under reduced pressure
  2. customthe crystals precipitated
  3. customwere separated by filtration
  4. customThe crystals thus obtained
  5. washwere washed with ethylether

출처 및 근거

ORD 기록
ord-a15db979ebc54b889a356f3f03824796
출처 데이터셋
uspto-grants-1987_01
특허 번호
US04634770

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