Sulfate Ion → N-(2-((2-hydroxy-3-(4-(2-methoxyethoxy)phenoxy)propyl)amino)ethyl)-4-morpholinecarboxamide

HRID 980159노트

반응식

HRID 980159 반응식
[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:16]=[CH:15][C:9]([O:10][CH2:11][CH:12]2[O:14][CH2:13]2)=[CH:8][CH:7]=1.S([O-])([O-])(=O)=O.[NH2:22][CH2:23][CH2:24][NH:25][C:26]([N:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1)=[O:27].C([O-])([O-])=O.[K+].[K+]>CC(O)C>[OH:14][CH:12]([CH2:11][O:10][C:9]1[CH:15]=[CH:16][C:6]([O:5][CH2:4][CH2:3][O:2][CH3:1])=[CH:7][CH:8]=1)[CH2:13][NH:22][CH2:23][CH2:24][NH:25][C:26]([N:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1)=[O:27]

참가 물질

6

반응물 4

HCID 1117Sulfate IonHCID 11430Potassium CarbonateHCID 11041198N-(2-Aminoethyl)-4-morpholinecarboxamideHCID 126215491-(2,3-Epoxypropoxy)-4-(2-methoxyethoxy)benzene

생성물 1

HCID 20222106N-(2-((2-hydroxy-3-(4-(2-methoxyethoxy)phenoxy)propyl)amino)ethyl)-4-morpholinecarboxamide

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

4 g of 3-(4-(2-methoxyethoxy)phenoxy)-1,2-epoxypropane, 5.8 g of the sulphate of N-2-aminoethyl-4-morpholinecarboxamide, and 5.8 g of K2CO3 were refluxed in 2-propanol for 2 days. The mixture was filtered and concentrated in vacuo. The residue was dissolved in methylene chloride and washed with H2O. The organic phase was dried over Na2SO4, filtered and evaporated. The product was recrystallized from ethyl acetate. Yield 2.3 g. Melting point 69° C. (base). The structure was determined using NMR and equivalent weight.

후처리

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated in vacuo
  3. dissolutionThe residue was dissolved in methylene chloride
  4. washwashed with H2O
  5. dry with materialThe organic phase was dried over Na2SO4
  6. filtrationfiltered
  7. customevaporated
  8. customThe product was recrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-ef615be404514c78b21cfad46faf6846
출처 데이터셋
uspto-grants-1987_01
특허 번호
US04636501

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