5-Chloro-2(1H)-pyrimidinone → 5-Chloro-1-(4-methylsulphinylphenacyl)pyrimidin-2-one

HRID 980180노트

반응식

HRID 980180 반응식
[Cl:1][C:2]1[CH:3]=[N:4][C:5](=[O:8])[NH:6][CH:7]=1.Br[CH2:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([S:19]([CH3:21])=[O:20])=[CH:15][CH:14]=1)=[O:12]>C(N(CC)CC)C.C(O)C>[Cl:1][C:2]1[CH:3]=[N:4][C:5](=[O:8])[N:6]([CH2:10][C:11]([C:13]2[CH:18]=[CH:17][C:16]([S:19]([CH3:21])=[O:20])=[CH:15][CH:14]=2)=[O:12])[CH:7]=1

참가 물질

5

반응물 2

HCID 1085785-Chloro-2(1H)-pyrimidinoneHCID 127955374-Methylsulphinylphenacyl bromide

생성물 1

HCID 127955465-Chloro-1-(4-methylsulphinylphenacyl)pyrimidin-2-one수율 54.6%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 8471Triethylamine용매

실험 절차

A suspension of 5-chloropyrimidin-2-one (399 mg). and 2-bromo-4'-methylsulphinylacetophenone (784 mg) in triethylamine (1 ml) and ethanol (20 ml) was stirred at ambient temperature for one hour, when the resulting suspension was chilled in ice. The collected solid was crystallised from ethanol to give the title pyrimidinone (509 mg,); m.p. 219°-220°; λmaxEtOH 233.5 nm (ε 17920), 332 nm (ε 2060), λinf 266 nm (ε 9280).

후처리

  1. temperaturewhen the resulting suspension was chilled in ice
  2. customThe collected solid was crystallised from ethanol

출처 및 근거

ORD 기록
ord-f6f43282221c4ea9a03bb8905fb42953
출처 데이터셋
uspto-grants-1987_01
특허 번호
US04636509

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