Ammonia → HCID 13365190, 화합물

HRID 980191

반응식

HRID 980191 반응식
[OH:1][C:2]1([C:12]2[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][CH:13]=2)[CH2:7][N:6]([CH3:8])[CH2:5][C:4]2[O:9][CH:10]=[CH:11][C:3]1=2.N.B(F)(F)F.[CH3:24]O>>[CH3:24][O:1][C:2]1([C:12]2[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][CH:13]=2)[CH2:7][N:6]([CH3:8])[CH2:5][C:4]2[O:9][CH:10]=[CH:11][C:3]1=2

참가 물질

4

반응물 3

HCID 222AmmoniaHCID 11062313Boron, trifluoro(methanol)-, (T-4)-HCID 13365189HCID 13365189, 화합물

생성물 1

HCID 13365190HCID 13365190, 화합물

실험 절차

Two grams (0.005 mol) of 4-hydroxy-4-(p-bromophenyl)-6-methyl-4,5,6,7-tetrahydro-furano[2,3-c]pyridine were heated to 50° C. for four hours in 40 ml of a boron trifluoride/methanol mixture (20% BF3), and then the mixture was poured onto ice and neutralized with ammonia. The mixture was extracted with ether, and the ether was distilled off in vacuo. The residue was purified over silica gel [cyclohexane/ethyl acetate (75:25)].

후처리

  1. extractionThe mixture was extracted with ether
  2. distillationthe ether was distilled off in vacuo
  3. customThe residue was purified over silica gel [cyclohexane/ethyl acetate (75:25)]

출처 및 근거

ORD 기록
ord-45c10db0ae894399ad0c761ab202228d
출처 데이터셋
uspto-grants-1987_01
특허 번호
US04636510

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