18-Crown-6 → N-chloroacetyl-N-methylcarbamoyl fluoride
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[Cl:1][CH2:2][C:3]([N:5]([CH3:9])[C:6](Cl)=[O:7])=[O:4].[F-:10].[K+].C1OCCOCCOCCOCCOCCOC1>ClCCl>[Cl:1][CH2:2][C:3]([N:5]([CH3:9])[C:6]([F:10])=[O:7])=[O:4]참가 물질
5
실험 절차
A mixture of 10.0 g of N-Chloroacetyl-N-methylcarbamoyl chloride, 3.8 g of anhydrous potassium fluoride and 0.5 g of 18-crown-6 in 50 cc of dichloromethane was stirred at room temperature under nitrogen for about 16 hours. The liquid was decanted and the residue was extracted with 50 cc dichlormethane. The dichloromethane layers were combined and the solvent stripped off to afford 9.0 g. (Yield 100%) of N-chloroacetyl-N-methylcarbamoyl fluoride. The product was further purified by distillation under reduced pressure. B.p. 59° C./0.2 mm.
후처리
- customThe liquid was decanted
- extractionthe residue was extracted with 50 cc dichlormethane
- customto afford 9.0 g
출처 및 근거
- ORD 기록
- ord-004ef200fc5841ada6f0de7397b9b257
- 출처 데이터셋
- uspto-grants-1987_01
- 특허 번호
- US04637901
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