Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydroxide → 3-(Pyrazin-2-yl)acrylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydroxide | HCID 961 | — |
| 반응물 | Chloral | HCID 6407 | — |
| 반응물 | 2-Methylpyrazine | HCID 7976 | — |
| 반응물 | 2-(Pyrazin-2-yl)propanoic acid | HCID 17864951 | — |
| 생성물 | 3-(Pyrazin-2-yl)acrylic acid | HCID 305608 | — |
반응 단계
Scheme M depicts a specific synthesis of a pyrazinyl propionic acid. Methylpyrazine anion is condensed with trichloroacetaldehyde followed by treatment with base (hydroxide), then acidification to produce 3-(-Pyrazinyl) Acrylic Acid 75. This acid is then catalytically hydrogenated over palladium on charcoal to yield 3-(2-Pyrazinyl)propionic Acid 76.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04638005 |
| 출처 데이터셋 | uspto-grants-1987_01 |
| ORD ID | ord-c13ea9ac38ac4cf591514329645f7d16 |
| 출처 메모 | uspto-grants-1987_01 |