Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 6-Propionyl-3-methyl thiochromane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Propionyl chloride | HCID 62324 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 반응물 | 3-Methyl-thiochromane | HCID 12308537 | — |
| 용매 | 1,2-Dichloroethylene | HCID 10900 | — |
| 생성물 | 6-Propionyl-3-methyl thiochromane | HCID 54530528 | — |
반응 단계
To 0.13M of AlCl3, 0.12M of propionyl chloride in 150 ml of 1,2-dichloroethylene, 0.1M (16.4 gr.) de 3-methyl-thiochromane are dropwise added at a temperature of ±5° C. After agitating the mixture for 3 hours at room temperature, a mixture of ice and HCl is added and extraction is made with CHCl3. The organic phase is dried on MgSO4, filtered and evaporated. 17.3 gr. of 6-propionyl-3-methyl thiochromane are so obtained, the homogeneity of which is verified by TLC and the structure of which is verified by NMR spectrum.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04638070 |
| 출처 데이터셋 | uspto-grants-1987_01 |
| ORD ID | ord-8b058bd4b3774532b9045b91d321daa0 |
| 출처 메모 | uspto-grants-1987_01 |