Aniline → Dimethyl 2-(Phenylamino)-2-butenedioate

HRID 980550노트

반응식

HRID 980550 반응식
[CH3:1][O:2][C:3]([C:5]#[C:6][C:7]([O:9][CH3:10])=[O:8])=[O:4].[NH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C(Cl)CCl>[C:12]1([NH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][C:3]([O:2][CH3:1])=[O:4])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

4

반응물 2

HCID 6115AnilineHCID 12980Dimethyl acetylenedicarboxylate

생성물 1

HCID 2797953Dimethyl 2-(Phenylamino)-2-butenedioate

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매2회

실험 절차

To a stirred solution of dimethylacetylenedicarboxylate (DMAD, 0.10 mol) in 50 ml of ethylenedichloride (EDC), is slowly added a solution of aniline (0.10 mole) in 15 ml of EDC. The temperature of the reaction mixture is maintained below 30° C. and stirring is continued for about one hour until the reaction is essentially complete. The toluene is then removed under vacuum to afford the dimethyl 3-phenylaminobut-2-ene-dioate.

후처리

  1. temperatureThe temperature of the reaction mixture is maintained below 30° C.
  2. customThe toluene is then removed under vacuum

출처 및 근거

ORD 기록
ord-5d0bb406cac8456e9bda409ed4bee4aa
출처 데이터셋
uspto-grants-1987_01
특허 번호
US04638068

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